diff --git a/agent/anthropic_adapter.py b/agent/anthropic_adapter.py
index 5768ae3ea904..fc5503e41117 100644
--- a/agent/anthropic_adapter.py
+++ b/agent/anthropic_adapter.py
@@ -1582,7 +1582,10 @@ def _is_bedrock_model_id(model: str) -> bool:
     """
     lower = model.lower()
     # Regional inference-profile prefixes
-    if any(lower.startswith(p) for p in ("global.", "us.", "eu.", "ap.", "jp.")):
+    if any(lower.startswith(p) for p in (
+        "global.", "us.", "eu.", "apac.", "ap.", "au.", "jp.",
+        "ca.", "sa.", "me.", "af.",
+    )):
         return True
     # Bare Bedrock model IDs: provider.model-family
     if lower.startswith("anthropic."):
diff --git a/agent/bedrock_adapter.py b/agent/bedrock_adapter.py
index e65867921c45..d3e6dfcd101e 100644
--- a/agent/bedrock_adapter.py
+++ b/agent/bedrock_adapter.py
@@ -448,7 +448,10 @@ def is_anthropic_bedrock_model(model_id: str) -> bool:
     """
     model_lower = model_id.lower()
     # Strip regional prefix if present
-    for prefix in ("us.", "global.", "eu.", "apac.", "ap.", "au.", "jp."):
+    for prefix in (
+        "global.", "us.", "eu.", "apac.", "ap.", "au.", "jp.",
+        "ca.", "sa.", "me.", "af.",
+    ):
         if model_lower.startswith(prefix):
             model_lower = model_lower[len(prefix):]
             break
diff --git a/agent/chat_completion_helpers.py b/agent/chat_completion_helpers.py
index 6e583f2cae42..b2e5c8653a48 100644
--- a/agent/chat_completion_helpers.py
+++ b/agent/chat_completion_helpers.py
@@ -341,7 +341,10 @@ def _bedrock_reasoning_stale_floor(model_id: object) -> "float | None":
     if not model_id or not isinstance(model_id, str):
         return None
     name = model_id.strip().lower()
-    for prefix in ("us.", "eu.", "apac.", "ap.", "global.", "jp."):
+    for prefix in (
+        "global.", "us.", "eu.", "apac.", "ap.", "au.", "jp.",
+        "ca.", "sa.", "me.", "af.",
+    ):
         if name.startswith(prefix):
             name = name[len(prefix):]
             break